Vitamin D Modulates the Expression of IL-27 and IL-33 in the Central Nervous System in Experimental Autoimmune Encephalomyelitis

Authors

  • Abdollah Jafarzadeh Neuroscience Research Center, Institute of Neuropharmacology | Department of Immunology, Medical School, Kerman University of Medical Sciences, Kerman | Department of Immunology, Medical School, Rafsanjan University of Medical Sciences, Rafsanjan
  • Ali Shamsizadeh Department of Physiology, Medical School, Rafsanjan University of Medical Sciences, Rafsanjan
  • Maryam Nemati Department of Immunology, Medical School, Kerman University of Medical Sciences, Kerman | Department of Laboratory Sciences, Paramedical School, Kerman University of Medical Sciences, Kerman
  • Marziyeh Mohammadi-Kordkhayli Neuroscience Research Center, Institute of Neuropharmacology | Department of Immunology, Medical School, Kerman University of Medical Sciences, Kerman
  • Mohammad Khaksari Neuroscience Research Center, Institute of Neuropharmacology
  • Rayhane Ahangar-Parvin Department of Immunology, Medical School, Rafsanjan University of Medical Sciences, Rafsanjan
  • Sayed Mohammad Moazzeni Department of Immunology, Medical School, Tarbiat Modares University, Tehran, Iran
  • Sayed Vahab Azizi Department of Immunology, Medical School, Rafsanjan University of Medical Sciences, Rafsanjan
Abstract:

Background: It has been reported that vitamin D has broad anti-inflammatory and immunomodulatory effects. Objective: To evaluate the effects of vitamin D on the expression of IL-27 and IL-33 in a model of experimental autoimmune encephalomyelitis (EAE). Methods: EAE was induced in C57BL/6 mice by immunization with myelin oligodendroglial glycoprotein mixed with complete Freund's adjuvant. The mice were administered with PBS or olive oil, intraperitoneally, in the control groups and vitamin D (200 ng every two days) in the treatment group, from day +3 to +30. At day 31, the mice were scarified and their spinal cords and brains were harvested. The expression of the IL-27 and IL-33 mRNA in the spinal cord was measured using real time-PCR. Results: In PBS- or olive oil-treated EAE mice the expression of IL-27 P28 mRNA was significantly lower than that in the healthy control group (p

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Journal title

volume 12  issue 1

pages  35- 49

publication date 2015-03-01

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